Warren Beatty’s World Crumbling Around Him!

Family woes take their toll on the broken-down actor.

Warren beatty NEMONDAY

Movie legend Warren Beatty was exclusively snapped by The National ENQUIRER on his first public outing in over a year — and the reclusive 78-year-old seems headed for a breakdown!

The former “Shampoo” actor and noted ladies man has been ripped up by repeated issues with his children, friends said, and it’s left his marriage to fellow showbiz star Annette Bening, 57, in tatters.

“Poor Warren looks like a shadow of his former self,” an eyewitness told The ENQUIRER after seeing the star in L.A. on Jan. 18. “He seems to have the weight of the world on his shoulders.

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“It looks like he’s headed for a breakdown with all of his heartache over his kids!”

The ENQUIRER learned his college-student daughter, Isabel, is battling a prescription pill addiction and trying to stay sober while her former sister has moved out on the family and is in a transgender trial marriage!

“The family strife is making him sick,” said a pal. “He and Annette can’t seem to agree on how to handle their out-of-control kids.”

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Isabel, a 19-year-old freshman at San Francisco State University, recently took to social media and confessed to a Xanax addiction while battling to stay on the wagon.

“I don’t want anyone to have to go through what I feel right now. Honestly feel like I’m gonna die,” Isabel posted in December.

Warren and Annette may have the riches of their two Hollywood careers spread over the last six decades to fall back on, but their family is proof that money isn’t everything. Isabel isn’t the only one of Warren and Annette’s four kids to reveal a personal crisis — their eldest child, Stephen Ira, 24, who was born Kathlyn, began a gender transition at age 14.

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“Warren and Annette love their son, but it’s been difficult accepting Stephen’s change,” said the source. “Warren is old school and all this has knocked him for a loop.”