"YOU make me sick!" An irate JANET JACKSON hurled those angry words at Oprah Winfrey over the talk-show queen’s blockbuster interview with her late brother Michael‘s three children, pals say.

Janet feels Oprah has betrayed the Jackson family, sources say, and she plans to expose the talk-show queen’s dirtiest secrets in revenge – with help from their mutual friend, filmmaker Tyler Perry.

"Janet is furious," a close family friend told The ENQUIRER.

"She thinks Oprah took advantage of Michael’s children for TV ratings. Janet told her Michael would be heartsick that Oprah used his kids as pawns."

"The two women had a blistering blowup during a telephone call on the day that the show was taped," said the friend. When Oprah made it clear that she was going ahead with the interview, Janet screamed: "Oprah, you make me sick!"

Adding fuel to the fire, the interview aired back-to-back with an Oprah Winfrey Show about 200 men who had been sexually molested.

Perry appeared on that show, and the actor/director- best known for cross-dressing as movie character Madea in Diary of a Mad Black Woman – has been dragged into the feud, insiders say.

Perry, 41, has been close to Oprah since vacationing with her in Italy in July 2008, but he’s also directed Janet in the movies For Colored Girls, and Why Did I Get Married? and its sequel.

"Janet is closer to Tyler, and Oprah knows it. Now Janet is threatening to use that friendship to get back at Oprah," said the source.

"Janet has let Oprah know that Tyler has been very candid about sharing Oprah’s secrets with her – and Oprah’s definitely got secrets.

"Janet is so outraged that she’s not above getting back at Oprah by spreading those secrets."

Oprah invited Janet to talk about her beloved brother on her show that aired Nov. 8, but Janet flatly refused, said an insider.

"There’s no way Oprah coincidentally produced a show on sexual abuse and aired it so close to her interviews with Michael’s children," the source said.

Get all the details of their WAR in the ENQUIRER – still on sale!