Pregnant “Friends” star Courteney Cox suffered a devastating miscarriage in her first trimester and lost one of the twins she was carrying, The ENQUIRER has learned exclusively.

But the brave beauty is grateful that she and husband David Arquette have made it to the third trimester with the remaining baby.

The issue that goes on sale Friday reveals why Courteney and David chose an in vitro procedure for the pregnancy, how the couple are eagerly awaiting the expected July birth … and more.