DREW’s brother JOHN BARRYMORE III blasts her over half-sister Jessica’s booze and drug related death.

 Despite her staggering $125 million fortune, “Charlie’s Angels” star Drew Barrymore coldly turned her back on her troubled half-sister Jessica, who died a lonely booze- and drug-related death late last month.

That’s the angry charge of her half-brother, John Blyth Barrymore III, who told The National ENQUIRER in an exclusive interview: “Drew barely knew Jessica. That’s because she’s been avoiding the rest of her family for years!”

According to a published report, Drew, 39, allegedly once made a childhood put-down of her sister, which may have fueled Jessica’s lifelong obsession with her weight.

Drew reportedly said: “How could I possibly be related to someone who is so fat?”

Jessica’s surrogate mother, Dorothy Steinbeck, said her daughter suffered from serious self-esteem issues.

John, 60, told The ENQUIRER: “Drew last met Jessica when we were scattering our father’s ashes at Joshua Tree (in the Southern California desert) in 2004, and that was about it. She has a wall of people who have cut us off.”

Jessica was found dead July 29, just two days shy of her 48th birthday.

Her body was discovered inside a parked Toyota Camry in National City, Calif., just north of San Diego.

Jessica, who worked at a suburban Petco and had a previous drug arrest, “appeared to be sleeping in her vehicle,” said National City Police Lieutenant Robert Rounds.

According to reports, vodka, methamphetamine and dozens of white pills were found in the car, and an autopsy was planned to determine the cause of death.

“I know she would have loved to have been closer to Drew,” Jessica’s co-worker Cara Dysert told RadarOnline, “but Drew didn’t want to be close to her siblings.”

Ironically, mom-of-two Drew, like other Barrymores, has been cursed with her own past drug and alcohol demons and has done three stints in rehab.

“Still, that’s no excuse for her to turn her back on them,” said a close source. “She should feel guilt and shame over Jessica’s death – she’s done nothing to help her family.”

Drew, who is married to art dealer Will Kopelman, responded to Jessica’s death with an official statement: “Although I only met her briefly, I wish her and her loved ones as much peace as possible, and I’m so incredibly sorry for their loss.”