Alexis Arquette: ‘Caitlyn Jenner Ruined My Career!’

Alexis Arquette died a bitter and broken man — after Hollywood left him feeling betrayed over being a woman! Insiders tell The National ENQUIRER that the busy starlet became a recluse in her final days because she couldn't hide his resentment toward Tinseltown's dismissal of his talents. RadarOnline has revealed her brave struggle as she lost her life to AIDS, but pals say that her spirit was taken long ago!

Alexis — who was the grandson of "Hollywood Squares" legend Charley Weaver — began acting as a child, and played men in movies including "Pulp Fiction" and "Bride of Chucky." He also worked regularly in drag before deciding to become a woman — as captured in a 2007 documentary made by brother David Arquette, who was then married to Courteney Cox. But that disastrous decision left Alexis going after Hollywood figures ranging from Caitlyn Jenner to Sharon Osbourne!

"Alexis had this vision that she was going to capitalize on being a pioneer," said a pal, "but she thought that meant always having to look like a transsexual! Meanwhile, Hollywood began to cast transsexuals who looked fully transitioned. The only major role Alexis got after her surgery was in 'Blended' with Adam Sandler — and that was only because Courteney and Adam are friends!"

But Alexis' family connections left her feeling used by Sharon Osbourne — ruining her own ambitions to work as an entertainment reporter. "Sharon tried to make me her gossip columnist for her gossip segment on her old talk show," complained Alexis, adding that it was a ploy to "squeeze out some information from me about Courteney Cox being pregnant!"

Sadly, the betrayal didn't end there. "She used my footage of me saying Courteney was pregnant to get Courteney on her failing show," claimed Alexis. "She said to Courteney, 'I won’t use that footage of Alexis if you come on.' I’ve never trusted Sharon Osbourne!"

Alexis also fumed over another famous family stealing her chances for the spotlight, dismissing Caitlyn Jenner as a fraud. "He had his nails done and he had a blowout," Alexis said dismissively when Bruce Jenner began his transition.

"Alexis hated Caitlyn," added the insider. "She thought Caitlyn was like a Beverly Hills housewife, and it made her furious that Bruce Jenner had his own family connections to get a show on the E! network!"

David Arquette even told Khloé Kardashian that Caitlyn had made Alexis question his sex change. "I think because of Caitlyn," David said, "she's, like: 'I did that already. Now let's take it to the next level!'"

Sadly, Alexis' plans were cut short by AIDS and her own bitterness toward Hollywood. And while she was taken in by her family towards the end, Alexis also felt betrayed by her sister Patricia. "Her show 'Medium' ran for six seasons," said the insider, "and Alexis ended up being the only member of the Arquette acting family who never worked on it. Nobody in the family even told her when Patricia was nominated for an Oscar in 2015!"

But in a touching tribute, Patricia came forward to release the Arquette family's statement on Alexis' passing — with her doomed brother-turned sister having having gone quiet after getting caught in one last Hollywood scandal. Said the friend: "It means a lot to us that Patricia stepped up to make the family's official announcement about Alexis' death!"