Jennifer Aniston is heading back to primetime TV! Aniston will appear on Oprah Winfrey's ABC series Oprah's Big Give to make a "major" announcement.

The one-hour program is devoted to helping people across the country in financial need.

Aniston, who is currently filming Marley and Me with Owen Wilson in Florida, is no stranger to the power of giving back. She just teamed up with best pal Courteney Cox to raise $1 million for Epidermolysis Bullosa.

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