Rosie O’Donnell is reeling from a terrifying drug nightmare that left her depressed, weeping and teetering on the brink of a complete breakdown.

The star — who’s been taking antidepressant drugs for the past three years — has spent days in bed, refusing to talk to anyone, sleeping through the day, watching TV and eating junk food.

The issue that goes on sale Friday also reveals how a doctor’s intervention is helping Rosie bounce back, how she’s wreaking havoc at her magazine Rosie … and much more.