Rosie O’Donnell is facing a devastating family tragedy: She had to give up her beloved 3-year-old foster-child Mia, who is severely emotionally handicapped, for treatment at a mental health facility.

“I’m praying they don’t tell me she can’t come back to us,” a tearful Rosie told The ENQUIRER in an exclusive interview.

The issue that hits stands April 20, 2001 reveals why Rosie was eager to take in a “special needs” child, her concern for the safety of her three adopted children, her recent hospitalization in a life-threatening medical crisis — and much more.