Rosie O’Donnell’s weight has soared to 300 pounds — putting her in danger of a heart attack or stroke.

The 5-foot-7 comedienne is “in a fight for her life,” reveals a frightened friend, adding: “Her blood pressure is through the roof.”

The talk queen’s longtime lover — who’s four months pregnant with the child they plan to raise together — is desperately trying to get her to lose weight.

In The ENQUIRER that goes on sale Friday, you’ll discover the startling reasons behind Rosie’s health crisis … the secret insecurity that drives her … the effect the extra pounds are already having on her … plus much, much more!