"I hate you!"

Oprah Winfrey was devastated when best pal Gayle King shouted those venomous words, ripping apart their legendary friendship that had lasted more than 30 years.

In a shocking public spectacle, the talk queen and her once-closest companion erupted in a nasty confrontation that outraged Gayle and left their relationship dangling by a thread.

"It’s getting real ugly," revealed a close friend of Oprah. "They’re at each other’s throats!"

An embittered Gayle is striking back by cozying up to President Obama and the first lady — trying to infuriate the talk queen who is extremely proud of her uniquely close relationship with the first family, say sources.

And in a startling twist, the public clash has prompted the billionaire media mogul to arrange the return of on-again, off-again boyfriend Stedman Graham.

Get all the details in this week’s ENQUIRER — on newsstands now!