The most recognizable “Little Couple” on TV are reaching out to the stars of “Little People, Big World” after their marriage fell apart.

Dr. Jennifer Arnold and Bill Klein of TLC’s “Little Couple” were heartsick to learn that fellow TLC stars Matt and Amy Roloff were splitting up after 26 years, said a source.

“Dr. Jen and Bill feel for the Roloff family,” revealed the insider.

“They know the struggles ‘little people’ face and were happy that the Roloffs were adding another posi­tive image to their common condition.”

Both couples have forms of dwarfism. Matt, 52, and Amy, 50, have four children – 23-year-old twins Zach and Jeremy – who recently got engaged to girlfriend Audrey – Molly, 20, and Jacob, 17. Only Zach is a little person.

“Though we have weathered many storms together,” the couple said in a recent statement, “we recently made the tough decision to engage in a trial separation.”

The Roloffs’ show has aired since 2006 as a series and specials, and rumblings of trouble between them date back to 2010.

“Dr. Jen and Bill have been rooting for them and hope they can find a way back to where they once were, for the sake of the family,” said the insider.

Dr. Jen and Bill, both 39 – who have two adopted little people, Will, 4, and Zoey, 2 – have faced their own tough times recently as Jen battled cancer.

As The ENQUIRER reported, experts were optimistic she would beat Stage 3 choriocar­cinoma, a rare cancer that formed during a nonviable pregnancy.

After undergoing surgery and chemo­therapy, 3-foot-2 Dr. Jen – a neonatologist at Houston’s Texas Chil­dren’s Hospital – is now cancer-free.

Meanwhile, she remains concerned about the Roloffs, said the source.

“Dr. Jen is such a loving person,” praised the insider. “She’s always thinking of others. She reached out to let Matt and Amy know if there’s anything they need, all they have to do is ask.”