THE Kardashian clan ruined Lamar Odom’s life! That’s the claim of the former L.A. Lakers star’s father Joe Odom – who blasts the entire reality TV family and says marrying Khloe was the worst mistake Lamar ever made.

“The Kardashians don’t give a f*** about my son,” Joe declared. “They brought him down. Lamar would be better off without them.”

Lamar, 33, stands accused of using crack cocaine and cheating on his 29-year-old wife Khloe with several other women. Lamar has denied having a crack problem, but Joe blames the Kardashians for his son’s problems.“I wish Lamar had never married Khloe,” he said. “She’s controlling. I think the best thing for him would be to divorce her and try to get his life together as a single man.”

But Joe saved his angriest words for Lamar’s mother-in-law.

“Kris Jenner is an evil witch,” seethed the 59-year-old former post office worker, who lives in Marina del Rey, Calif.

“She doesn’t care about Lamar. She just cares about their image and money.”

He also blasted Khloe’s sister Kim for having the audacity to judge his son after a sex tape made her a household name.

“I heard Kim say that they don’t have crackheads in their family,” fumed Joe. “But look at where she came from. We don’t want porn stars in our family!”

Joe has been in regular contact with Lamar, who entered rehab on Sept. 5, but left after one day. Lamar was also recently busted for drunk driving and was spotted buying copper scrubbing pads, which are commonly used in homemade crack pipes.

“I love my son,” said Joe, an ex-addict who’s been sober for 15 years. “But if he’s abusing drugs, my advice to him would be: GO to rehab.”