By George, Clooney loves to pull practical jokes!

The “Intolerable Cruelty” star showed intolerable cruelty to Richard Kind of “Spin City” when they shared an apartment together. George told Kind their cat was constipated, but what Kind didn’t know was that George was emptying the feline’s litter box every day so it always appeared empty.

George capped off the joke by leaving his own deposit in the litter box — and Kind was floored when he saw the size of it!

The actor once rigged a bucket of water over the door to Julia Roberts‘ hotel room. Fortunately for the “Pretty Woman,” a porter opened the door first and got doused.

George handed out fat bonuses to Julia and his other “Ocean’s Eleven” co-stars Brad Pitt and Matt Damon — with fake money!

Clooney also made his “Confessions of a Dangerous Mind” co-star Sam Rockwell the butt of a joke, changing the “Do Not Disturb” sign on his hotel room door to a request for breakfast — at 6 a.m.!