EVA LONGORIA blasted GEORGE LOPEZ and threatened to end their friendship after he took a nasty swipe at his ex-wife.

The “Desperate Housewives” star and the 51-year-old comedy king clashed while serving on a committee for a celebration of Latino art and culture at the Kennedy Center in Washington, D.C.

“George and Eva are longtime friends, and over the years she’s grown especially close to his ex-wife Ann Serrano,” an insider told The ENQUIRER.

“She’s never really forgiven George for dumping Ann after she donated her kidney to him when he needed a transplant.”

And all hell broke loose when George called Ann “stupid” for dating notorious ladies’ man, actor Michael Nouri, added the source.

As The ENQUIRER recently reported, Ann’s pals fear that “Flashdance” star Nouri, 67, is after the $25 million Ann, 52, was awarded in her divorce from Lopez.

But loyal Eva, 37, blew a gasket at her pal’s insensitive comment.

She was holding a glass of water and got so hot she said she nearly hurled it at George,” divulged the source.

“Eva told him that he had one hell of a nerve criticizing Ann after everything she’d done for him. She demanded that George apologize and even threatened to get him thrown off the committee if she ever heard of him criticizing his ex again.

“George said he was sorry and sheepishly passed it off as a bad joke. In the end, Eva forgave him. But she also warned George that he’d better mind his manners in the future.”