Serial dater GEORGE CLOONEY scores another bed partner – supermodel CINDY CRAWFORD.

But his main squeeze Stacy Keibler and Cindy’s hubby, restau­rateur Rande Gerber, didn’t even blink an eye – because all four play musical beds in a hilarious TV commercial.

The outrageous ad spoofs the Oscar-winning actor’s bed-hopping image while touting Casamigos, a tequila that he’s developed with his best bud Rande.

“They were all sitting around one night sipping tequila when George got this outrageous brain­storm to cast them all in a sex farce to introduce their new line of booze,” an insider told The ENQUIRER.

“George knows his reputation as a perpetual playboy almost rivals his acting career, so he decided to have fun with it.

“He thought it would be a hoot to play off his lady-killer image.”

So the 51-year-old “Ocean’s 11” hunk plotted out the short ad titled, “It Could Happen. Please Drink Responsibly.”

It opens with Rande walking in on Cindy in bed with George and asking: “What’s going on?” as Cindy pulls up the sheet to hide her sexy red negligee.

In the next scene, a stunned George stumbles upon Stacy and Cindy together in bed – and in the final scene, Stacy and Cindy exchange quizzical looks after finding Rande sharing the sheets with his pal, George.

“George is definitely not one to take himself too seriously and he’s so shrewd,” the source said.

“Not only is he promoting one of his business ventures, he’s also goosing his loverboy image!”