Oprah Winfrey flew into a rage after being slammed in a bombshell report that charges she dispenses dangerous medical advice on her show.

"Oprah had a major meltdown," a show insider told The ENQUIRER after she was the subject of a blistering June 8 cover story in Newsweek magazine, titled "CRAZY TALK Oprah, Wacky Cures & You."

"She really let her producers have it - she went on a rampage.

"The article makes it look like she has knowingly misled her audience for years.

"But in reality, she trusted her guests - and her producers - to make sure their information was accurate."

For a full disclosure from Top Doctors who warn how talk show misinformation "can kill you" pick up the latest ENQUIRER - still on sale.